2026-2027 Academic Catalog

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Biomedical Engr & Sciences (BMES)

BMES 2004 - Concussion Perspectives: Medical, Scientific and Societal Perspectives (3 credits) 
Broad, multidisciplinary description of concussion as it relates to variety of fields including: medicine, psychology, injury biomechanics, technology, equipment design, ethics, and law. Concussion modeling, animal models, diagnosis, neurocognitive testing, and treatment. Testing and instrumentation. Research efforts, credibility and conflicts of interest. Ethical considerations in sports, medicine, and science. Legal implications.
Pathway Concept Area(s): 1A Discourse Advanced, 4 Reasoning in Natural Sci., 10 Ethical Reasoning 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 2014 - Biomedical Engineering Professional Practice (1 credit) 
Topics selected to foster professional development of the Biomedical Engineering (BME) student, including training for experiential learning opportunities, such as research, internships, co-ops, and design. Overview of BME specialization and research areas, career pathways, and preparation for interactions with industry, including the regulatory approval process associated with medical device development. Emphasis on teamwork, communication, employment opportunities, the development of a professional portfolio, ethical considerations, additive manufacturing, and engineering documentation using real-world examples and a design sprint/challenges.
Instructional Contact Hours: (1 Lec, 1 Crd) 
BMES 2024 - ESTEEMED Program Seminar (1 credit) 
Professional development seminar series for National Institutes of Health (NIH) Enhancing Science, Technology, EnginEering, and Math Educational Diversity (ESTEEMED) program scholars. Professional development and construction of professional portfolio. Overview of safety and ethical considerations within biomedical engineering research. Development of scientific literature searching and summarizing skills. Communication skill development of written and oral content. Strategies for mentoring relationships. May be repeated 3 times with different content for a maximum of 4 credit hours. Pre: Only available to students in the ESTEEMED program.
Instructional Contact Hours: (1 Lec, 1 Crd) 
Repeatability: up to 4 credit hours 
BMES 2054 - Electrical Principles for Biomedical Engineers (3 credits) 
Fundamentals of electrical circuits and their applications in biomedical engineering. Analysis of resistive, capacitive, and inductive components in AC and DC circuits. Application of Kirchoff’s laws, voltage and current dividers, impedance, and operational amplifiers. Introduction to active and passive filters, frequency domain analysis, and Laplace transforms. Hands-on laboratory exercises integrating circuit analysis with biomedical instrumentation, including sensors, data acquisition systems, and microcontrollers for conversion of analog biosignals.
Prerequisite(s): PHYS 2306 
Corequisite(s): MATH 2214 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 2074 - Computational Methods in Biomedical Engineering (2 credits) 
Numerical methods and software applied to biomedical engineering applications. Structured programming and problem solving within programming environment such as MATLAB. Error estimation, root finding, curve fitting, interpolation, solving linear simultaneous equations, numerical differentiation, numerical integration, and numerical solutions to ordinary differential equations.
Prerequisite(s): MATH 1226 and (ENGE 1215 or ENGE 1414) 
Corequisite(s): MATH 2114 or MATH 2114H or MATH 2405H 
Instructional Contact Hours: (2 Lec, 2 Crd) 
BMES 2104 - Introduction to Biomedical Engineering (3 credits) 
Identification, exploration, and evaluation of real-world, complex biomedical engineering problems including safety and ethical considerations. Emphasis on critical thinking, problem solving, group skills, and communication related to the field of biomedical engineering. Literature review and experimental design in biomedical engineering research.
Prerequisite(s): (ENGE 1216 or ENGE 1414) and MATH 1226 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 2974 - Independent Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 2984 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 2994 - Undergraduate Research (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 3004 - Helmet Design: Biomechanics to Health & Social Disparities in Sports (3 credits) 
Provides a multidisciplinary description of helmet design with applications to all sports. The biomechanical design parameters for helmets are presented in the broader context of health and social disparities. Through reasoning in the social sciences the class investigates how sex and gender roles have shaped sports and their individual helmet design disparities. A critical analysis of equity relative to race and healthcare is analyzed as it pertains to helmets and concussion treatments and outcomes. Demonstrate the interdisciplinary nature of helmet design and how ethical reasoning and social constructs have shaped the industry.
Pathway Concept Area(s): 3 Reasoning in Social Sciences, 7 Identity & Equity in U.S., 10 Ethical Reasoning 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3024 - BME Cell Engineering Laboratory and Design (2 credits) 
Principles of cell engineering, experiment design, quantitative alyses. Laboratory notebook keeping, report writing and oral presentation in a team setting. Measurement of biological molecules such as DNA, RNA, and proteins. Assessment of animal cell viability, migration, mechanics and interactions with biomaterials. Identification of cell phenotypes.
Prerequisite(s): BIOL 1105 
Instructional Contact Hours: (1 Lec, 3 Lab, 2 Crd) 
BMES 3034 - Bioinstrumentation Laboratory and Design for Living Systems (2 credits) 
Principles of biomedical sensors and their usage for experimental design. Collection of biological signals using analog signal amplifiication and filters, biopotentials, digital acquisition, digital filtering and processing. Analysis of physiological signals on living systems with focus on neural, cadiovascular, respiratory, and muscular systems using a group problem solving approach. Instrumental regulation and safety considerations.
Prerequisite(s): BMES 2104 and (ECE 3054 or BMES 2054) 
Instructional Contact Hours: (1 Lec, 3 Lab, 2 Crd) 
BMES 3114 - Needs Identification in Healthcare (3 credits) 
Define open-ended problem statements related to healthcare. Immersive clinical observation and transdisciplinary medical technology innovation. Needs exploration and screening, disease state fundamentals, and evaluation of existing solutions. User-centered research planning, contextual inquiry, data documentation, stakeholder and market analysis, and regulatory and reimbursement basics.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3124 - Introduction to Biomechanics (3 credits) 
Basic principles of biomechanics. Basic musculoskeletal anatomy. Application of classical mechanics to biological systems. Emphasis placed on mechanical behavior (stress and strain), structural behavior, motion, and injury tolerance of the human body. Biomechanics of medical devices and implants. Advances in safety equipment used in automotive, military, and sports applications.
Prerequisite(s): BMES 2104 and ESM 2204 and ESM 2304 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3134 - Introduction to Biomedical Imaging (3 credits) 
Introduction to major biomedical imaging modalities. Emphasis on X-rays, computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound, and optical imaging. Essential physics and imaging equations of the imaging system. Sources of noise and primary artifacts. Patient safety and clinical application.
Prerequisite(s): BMES 2104 and (MATH 2204 or MATH 2204H) and PHYS 2306 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3144 - Biomedical Devices (3 credits) 
Design and uses of biomedical devices for diagnosis and therapy of human and animal diseases. Disease eiologies, progression, risk factors, and epidemiology. Tissue, organ, and systems dysfunction and failure and relevance to life stages (pediatric, adolescent, adult, aged). Useful characteristics of engineered materials for device fabrication, including biocompatibility. Gaps between medical needs and current medical devices.
Prerequisite(s): BMES 2104 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3154 - Biosignal Processing and Classification (3 credits) 
Introduction to the concepts and applications of digital signal processing and machine learning on bioinstrumentation signals from physiologic systems. Emphasis on processing techniques for electrocardiogram (ECG), electromyography (EMG), and speech signals. Apply basic machine learning algorithms for diagnostic classification of biosignals.
Prerequisite(s): BMES 2104 and (CS 1044 or CS 1054 or CS 1064 or CS 1114 or ME 2004 or AOE 2074 or ESM 2074 or BSE 3144 or BMES 2074) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3164 - Fundamentals of Regenerative Medicine and Tissue Engineering (3 credits) 
Fundamentals of cell biology, physiology, and engineering of regenerative medicine. Techniques and technologies of regenerative medicine and tissue engineering. Biomaterial selection and manufacturing techniques for regenerative medicine and tissue engineering applications. Overview of genetic and immuno- therapies. Design criteria and process from bench to clinical implementation of tissue engineering solutions. Ethical implications in regenerative medicine.
Prerequisite(s): BMES 4064 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3184 - Problem Solving in BME (3 credits) 
Computational and analytical approaches to analyzing biological systems and solving biomedical engineering problems. Problem formulation and exploration of problem-solving techniques to validate computational solutions. Self-directed inquiry and team-based approaches that use reverse engineering, user-in-mind design, and engineering software tools.
Prerequisite(s): BMES 2014 and BMES 2104 and (ESM 2074 or BMES 2074) and MATH 2214 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3224 - Automobile Safety (3 credits) 
Provides multidisciplinary analysis of automobile safety around the world. Illustration of the details about the invention of the wheel and how various cultures advanced the wheel into carts for transportation. Design process of seatbelt systems, frontal airbag and side airbag systems. Analysis of vehicle design parameters to optimize restraint systems. Analysis of the design challenges of protecting all occupants including men, women, children, elderly and pregnant occupants. Ethical analysis of the history of laws, media, and societal norms around seatbelt use and current distracted drivers using cell phones.
Pathway Concept Area(s): 6D Critique & Prac in Design, 10 Ethical Reasoning 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3234 - Foundations of Biotransport (3 credits) 
Introduction to fundamental principles of fluid mechanics, mass, momentum, and energy transport in physiological systems (tissue, organs, whole body) and biomedical devices. Application of differential equations to physiological systems. Diffusion, convection, and reaction kinetics in physiological and biomedical contexts. Applications include blood flow, oxygen transport, drug delivery, and biomaterials transport.
Prerequisite(s): BIOL 1105 and MATH 2204 and MATH 2214 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3704 - Computer Aided Design for Biomedical Engineering Applications (3 credits) 
Principles and applications of computer-aided design (CAD) for engineering and biomedical design intent and optimization. SolidWorks for 3D modeling, drafting, and assembly of components and structures. Integration of SolidWorks with computational tools for finite element analysis (FEA) and structural validation. Creation of machine design elements and assemblies for practical engineering and medical device applications. Preparation for the Certified SolidWorks Associate (CSWA) exam with guided practice and skill-building. Design reproducibility, efficiency, and manufacturing integration through CAD techniques. Professional standards for documentation.
Prerequisite(s): ESM 2204 or ESM 2114 or AOE 2014 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 3844 - Computational Neuroscience and Neural Engineering (3 credits) 
Introduction to computational and systems neuroscience. Data analysis and signal processing techniques for neural data. Neural modeling to include mean field models, Hodgkin-Huxley models, integrate and fire models. Neural engineering and brain machine interface (BMI) applications.
Prerequisite(s): MATH 1226 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: NEUR 3844 
BMES 3900 - Bridge Experience (0 credits) 
Application of academic knowledge and skills to in a work-based experience aligned with post-graduation goals using research-based learning processes. Satisfactory completion of work-based experience often in the form of internship, undergraduate research, co-op, or study abroad; self-evaluation; reflection; and showcase of learning. Pre: Departmental approval of 3900 plan.
Instructional Contact Hours: (0 Crd) 
BMES 3984 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 4015 - BME Senior Design and Project (3 credits) 
4015: Apply biomedical engineering principles to the design of an approved project using the team approach. Develop design and communication skills. Integrate ethical, global and social issues in engineering. 4016: Apply biomedical engineering principles to develop solutions for an approved design project using a team approach. Complete a project resulting in prototype medical device, circuit, or system. Refine design and communication. Integrate ethical, global, environmental and social issues in engineering. Pre: Senior standing for 4015.
Prerequisite(s): BMES 3034 and BMES 3184 and BMES 4064 and (ESM 2204 or ESM 2304) 
Pathway Concept Area(s): 1A Discourse Advanced, 10 Ethical Reasoning 
Instructional Contact Hours: (2 Lec, 3 Lab, 3 Crd) 
BMES 4016 - BME Senior Design and Project (3 credits) 
4015: Apply biomedical engineering principles to the design of an approved project using the team approach. Develop design and communication skills. Integrate ethical, global and social issues in engineering. 4016: Apply biomedical engineering principles to develop solutions for an approved design project using a team approach. Complete a project resulting in prototype medical device, circuit, or system. Refine design and communication. Integrate ethical, global, environmental and social issues in engineering. Pre: Senior standing for 4015.
Prerequisite(s): BMES 4015 
Pathway Concept Area(s): 1A Discourse Advanced, 10 Ethical Reasoning 
Instructional Contact Hours: (2 Lec, 3 Lab, 3 Crd) 
BMES 4024 - Advanced Cellular Engineering (3 credits) 
Advanced techniques and principles in cellular engineering. Identification of cellular markers through immunohistochemistry methods. Staining techniques for cell identification and characterization. Overview of microscopy and imaging technologies and cellular tracking applications. Analysis of static versus dynamic cell culture. Experimental design, relevant statistical approaches, and communication of scientific results.
Prerequisite(s): BMES 3024 
Instructional Contact Hours: (2 Lec, 3 Lab, 3 Crd) 
BMES 4034 - Wearable Bioinstrumentation (3 credits) 
Exploration of science, engineering, and data analytics principles behind wearable technology. Non-invasive measurement and assessment of human physiology and behavior. Data processing and analysis of non-invasive biosignals. Data privacy, protection, and ethical considerations of wearable devices.
Prerequisite(s): (CS 1044 or CS 1054 or CS 1064 or CS 1114 or ME 2004 or AOE 2074 or ESM 2074 or BSE 3144 or BMES 2074) and (STAT 3615 or STAT 3704 or STAT 4604) and (ECE 2054 or ECE 3054) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 4064 - Introduction to Medical Physiology (3 credits) 
An introductory to the principles of medical physiology. Designed primarily for (but not limited to), undergraduate students minoring in biomedical engineering, and other related engineering and physical sciences majors with little or no formal background in biological sciences. Basic principles and concepts of human physiology. Special emphasis on the interactions of human systems biology in their entirety rather than individual genes and pathways. Pre: Junior standing or permission of instructor.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 4084 - Cellular and Molecular Technologies in Biomedical Engineering (3 credits) 
Fundamental cellular and molecular concepts for biomedical engineering technologies. Genomics, transcriptomics, proteomics, molecular imaging and diagnostics. Nanotechnology and drug delivery systems. In-vitro technologies, molecular computing and bioinformatics. Applications and ethical considerations in biomedical engineering technologies
Prerequisite(s): BMES 3024 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 4134 - Global, Societal, and Ethical Considerations in Biomedical Engineering (3 credits) 
Overview of contemporary technological advances to improving human health. Comparison of healthcare systems, problems, and existing solutions throughout the developed and developing world. Consideration of legal and ethical issues associated with developing and implementing new medical technologies. Recognition and definition of gaps between medical needs and current methods and therapies between developed and developing countries. Conceptually design a novel technology.
Prerequisite(s): BMES 2104 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 4154 - Commercialization of BME Res (3 credits) 
Commercialization process applied to translational research. Regulatory aspects of biomedical engineering products and technologies (e.g. devices, diagnostics, drugs, biologics). Intellectual property, technology transfer processes, clinical trial design, commercialization of university research, modeling of development costs (e.g. cash flow and revenue projections). Small business startup approaches.
Prerequisite(s): BMES 2104 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 4214 - Musculoskeletal Biomechanics (3 credits) 
Skeletal anatomy and mechanics. Muscle anatomy and mechanics. Theory and application of electromyography. Motion and force measuring equipment and techniques including force platforms. Inverse dynamics modeling of the human body. Current topics in musculoskeletal biomechanics research.
Prerequisite(s): ESM 2304 and (CS 1044 or CS 1064 or CS 1114 or AOE 2074 or ESM 2074 or ME 2004 or BMES 2074) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 4204 
BMES 4224 - Biodynamics and Control (3 credits) 
Application of Lagrange mechanics to study of human movement dynamics and neuromuscular control of multi-degree-of-freedom systems. Computational simulation of forward-dynamics and state-space linear control of human movement to investigate functional performance and neuromuscular pathology.
Prerequisite(s): ESM 2304 and (CS 1044 or CS 1064 or CS 1114 or AOE 2074 or ESM 2074 or ME 2004 or BMES 2074) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 4224 
BMES 4234 - Mechanics of Biological Systems (3 credits) 
Anatomy and physiology of biological systems such as cells, tissues, and organs. Experimental techniques and mechanical tests for determining the mechanical behavior of biological systems. Simplified mechanics-based mathematical models of biological systems. Specific biological systems include cells, tissues, and organs of the musculoskeletal, cardiovascular, integumentary system, and reproductive systems.
Prerequisite(s): ESM 2204 and MATH 2214 and MATH 2114 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 4234 
BMES 4574 - Biomaterials (3 credits) 
Materials for biomedical applications. Basic material types and properties, functional uses of materials in medical applications, and tissue response mechanisms. Integrated design issues of multicomponent material design in prosthetic devices for hard and soft tissues, orthopedics , cardiovascular, and drug delivery applications.
Prerequisite(s): MSE 2034 or MSE 2044 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: MSE 4574 
BMES 4614 - Probability-Based Modeling, Analysis, and Assessment (3 credits) 
Uncertainty analysis of engineering data, parameters estimation, probability concepts, random variables, functions of random variables, probability-based performance functions and failure modes, risk and reliability functions, probability of failure and safety index, random sequences and stochastic processes, correlation functions and spectral densities, return period and extreme values, failure rates, performance monitoring and service life prediction.
Prerequisite(s): ESM 2204 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 4614 
BMES 4974 - Independent Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 4984 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 4984A - Special Study (1-19 credits) 
Pathway Concept Area(s): 1A Discourse Advanced 
Instructional Contact Hours: Variable credit course 
BMES 4994 - Undergraduate Research (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 4994H - Undergraduate Research (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 5004 - BME Ethics and Professional Development (1 credit) 
Socialization to the graduate student environment. Strategies for professional development and ethical standards in Biomedical Engineering. Virginia Tech’s ethical and academic values. Graduate Honor Code including plagiarism and scholarly citations. Ethical standards in academics. Ethical standards in biomedical research and reporting misconduct. Scientific communication across boundaries. Pre: Graduate standing in BME. Pass/Fail only.
Instructional Contact Hours: (1 Lec, 1 Crd) 
BMES 5024 - Biomedical Engineering and Human Disease (3 credits) 
Comprehensive overview of a variety of human diseases, including, neurological disorders, cardiovascular disease, infectious disease, and cancer, designed primarily for graduate students majoring in engineering and other related areas who have a long-term academic and professional goal in the field of biomedical engineering and life sciences. Introduction to state-of-the-art biomedical engineering approaches used for the study of early detection/diagnosis, treatment and prevention of human disease. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: BMVS 5224 
BMES 5044 - Engineering Mathematics (3 credits) 
Introduction to numerical solutions of partial differential equations using the finite element method in one-, two-, and three-dimensions with direct relevance to chemical engineering, biological systems engineering and biomedical engineering and sciences. Partial differential equations and ordinary differential equations using finite differences, model parameter sensitivity analysis, optimization, and data analysis. Pre-requisite: Graduate Standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: BSE 5044, CHE 5044 
BMES 5054 - Quantitative Cell Physiology (3 credits) 
Mathematical modeling, simulation, quantitative description of cell physiology and control. Numerical simulation of cellular physiologic processes including reaction kinetics, inhibition and cooperativity, passive transport, facilitated and carrier-mediate reaction kinetics. Cell resting membrane potential, and nerve and muscle tissue. Modeling of neural cell processes including voltage-gated channels, neurotransmitter kinetics, and postsynaptic cell membrane potentials.
Corequisite(s): BMES 5044 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5064 - Quantitative Organ Systems Physiology (3 credits) 
Mathematical modeling, simulation, quantitative description of organ physiology and control. Numerical simulation of cardiovascular physiologic processes including regulation of cardiac output, the baroreceptor - stroke volume model, venous return, and closed-loop control. Respiratory ventilation mechanics, gas exchange, pulmonary circulation, alveolar-capillary diffusion, and respiratory ventilation control. Nephron countercurrent mechanism and hemodialysis. Modeling of endocrine system functions.
Corequisite(s): BMES 5044 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5074 - Biomedical Research Design (3 credits) 
Design and analysis of research in the biomedical engineering fields. Ethical considerations. Experimental planning. Implementation of data collection plans. Statistical data analysis and interpretation of statistical results. Design and execution of clinical trials. Deployment of epidemiological studies. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5124 - Advanced Musculoskeletal Biomechanics (3 credits) 
Skeletal anatomy and mechanics. Muscle anatomy and mechanics. Theory and application of electromyography. Motion and force measuring equipment and techniques. Inverse dynamics modeling of the human body. Current topics in musculoskeletal biomechanics research. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 5224 
BMES 5154G - Advanced Commercialization of Biomedical Engineering Research (3 credits) 
Commercialization process applied to translational research. Regulatory aspects of biomedical engineering products and technologies (e.g. devices, diagnostics, drugs, biologics). Intellectual property, technology transfer processes, clinical trial design, commercialization of university research, modeling of development costs (e.g. cash flow and revenue projections). Small business startup approaches. Pre: Graduate Standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5164 - Advanced Impact Biomechanics (3 credits) 
A review of impact biomechanics and critical investigation of the impact response of the human body. Participants will study the dynamic response of the head, neck, chest, abdomen, upper extremities, and lower extremities. Real world examples from automobile safety, military applications, and sport biomechanics.
Prerequisite(s): (ME 3504 and ME 3614) or (ESM 3054 and ESM 3124) or (ME 3504 and ME 3614) or (ESM 3054 and ESM 3124) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5174 - Biomechanics of Crash Injury Prevention (3 credits) 
Principles of design and analysis of crash injury prevention methods in vehicle crashes. The course encompasses three major focus areas for occupant protection in crashes: crash energy absorption in (1) the vehicle structure, (2) the occupant, and (3) the occupant restraints. Topics include the biomechanics of impact injury, analysis of occupant response in crash tests, vehicle crash kinematics, modeling of vehicle impact response, modeling of human impact response, and occupant restraint design. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ME 5174 
BMES 5184 - Injury Physiology (3 credits) 
Introduction to the physiology of injury. Focus on the pathophysiology, mechanisms, and outcomes of injury in humans. Explores injury physiology at the organ, tissue, and cellular level. Topics include physiology of injury to the peripheral and central nervous systems, the musculoskeletal system, the pulmonary system, the abdomen, and the eye. Includes the injury physiology of adults as well as the special populations of children, pregnant females, and the elderly. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5204 - Laboratory Techniques in Injury Prevention (4 credits) 
Human surrogate biomechanical impact testing. 3-D rigid-body kinematics, kinetics, properties of deformable materials, servosled testing. Injury prediction and mitigation for transport systems. Transportation restraint system design. Instrumentation, data acquisition, and signal processing techniques of impact biomechanics. Pre: Graduate standing.
Instructional Contact Hours: (4 Lec, 4 Crd) 
Course Crosslist: ME 5204 
BMES 5214 - Human Physical Capabilities (3 credits) 
Focuses on the modeling, analysis, and evaluation of industrial workplaces with emphasis on the physical demands placed on and the capabilities of workers. Topics covered include: physiology, anthropometry, bioinstrumentation, and biomechanics. Students will learn and apply a range of contemporary analytical and assessment methods. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ISE 5614 
BMES 5234 - Advanced Vehicle Safety Systems (3 credits) 
Emerging challenges, applications, technology, tools, and agile management methods. Developing and evaluating safe next-generation ground transportation systems. Human and machine interactions. Epidemiological, empirical, and naturalistic approaches. Controlled test-track experiments. Design and development of advanced vehicle safety features. Collect, process, analyze, and interpret data. Driver behavior monitoring, collision avoidance, sensor, connected, and automated driving systems. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5274 - Advanced Laboratory Techniques in Injury Prevention (4 credits) 
Advanced biomechanical impact testing techniques and specialized measurement systems. Response corridors and injury risk functions. Advanced surrogate preparation techniques. High-speed 3D photogrammetry and spatial calibration. Motion analyses within multiple coordinate systems. High-Speed, biplane x-ray technique. Testing of hard biological materials. Fixture design and implementation. Data processing using global, local, and anatomical coordinate systems. Pre: Graduate standing.
Instructional Contact Hours: (4 Lec, 4 Crd) 
Course Crosslist: ME 5274 
BMES 5304 - Biological Transport Phenomena (3 credits) 
The fundamental principles of mass transport phenomena will be introduced and applied to the characterization of transport behavior in biological systems (e.g., cell, tissues, organs, people). Topics will include active, passive, and convective molecular transport mechanisms. These fundamentals will be used to develop analytical and predictive models that describe phenomena such as oxygen transport, kidney function, systemic drug delivery, and design of extracorporeal devices. Graduate standing required.
Prerequisite(s): CHE 3114 and (CHE 3044 or CHE 3144 or (ME 3304 and ME 3404 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: CHE 5304 
BMES 5305 - Biomechanics of the Cardiovascular System (3 credits) 
5305: Mechanics of the heart, arterial blood vessels and microcirculation; history of the circulation; anatomy and physiology of the heart; mechanics of cardiac contraction; cardiac fluid mechanics; work, energy, efficiency of cardiac function. 5306: Rheology of blood; hematology; elasticity of blood vessel walls; transport processes; control of the circulation; mathematical analysis of pulsatile blood flow and pulse-wave propagation through small arteries, capillary beds and extra-corporeal devices.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 5305 
BMES 5314 - Introduction to Regenerative Medicine (3 credits) 
Current state of the field of regenerative medicine with specific emphasis on the technological challenges that limit the efficacy and clinical translation of engineered tissues and therapies. Life science (e.g., call biology, organ physiology, biochemical methods) and engineering perspectives (e.g., stem cells, biologically-inspired materials, gene therapies) Prerequisite: Graduate Standing required
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5324 - Advanced Topics in Regenerative Medicine (3 credits) 
Advances in regenerative medicine, gene therapy, stem cell biology/therapy, biomaterials, tissue engineering, and the physiology of the major organ systems in both health and disease. Problem solving novel approaches to overcome limitations to engineer anatomically accurate and fully functional organ replacements to solve the unmet clinical need for donor organs.
Prerequisite(s): BMES 5314 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5414 - Biodesign Innovation Fundamentals (3 credits) 
Medical technology development course that provides students with an intensive and practical introduction to the process of biodesign innovation. Analyze the perspectives of various stakeholders and existing technologies while identifying opportunities for new products or services. Application of biodesign fundamentals, including needs exploration, needs statement development, needs selection, disease state fundamentals, stakeholder analysis, market analysis, intellectual property, regulatory and reimbursement strategy, ideation, and initial concept selection. Emphasis on teamwork and applied learning through the identification and development of a conceptual solution to an unmet medical need with consideration of technical, business, and healthcare metrics. Pre: Graduate standing
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5434 - Polymeric Biomaterials (3 credits) 
Topics include polymer design and processing, inflammatory responses to polymers, interaction of blood with polymeric materials, and the effect of mechanical, chemical, and surface properties of polymers on cells. The culmination of this course will provide students with the knowledge to successfully design polymer-based biomaterials, drug-delivery devices, and bio-implants. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: CHE 5214 
BMES 5514 - Digital Signal Processing for Mechanical Measurements (3 credits) 
The fundamentals of digital signal processing of data experimentally obtained from mechanical systems will be covered. Attention will be given to the data acquisition, A/D conversion, aliasing, anti-aliasing filtering, sampling rates, valid frequency ranges, windowing functions, leakage, and various transform methods. Special attention will be given to random, transient, and harmonic function data processing. Various methods of estimation of the frequency response function (FRF) will be explored. The estimation methods will be assessed as to their impact on FRF estimation errors.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ME 5714 
BMES 5525 - Stochastic Signals and Systems (3 credits) 
Engineering applications of probability theory, random variables and random processes. Time and frequency response of linear systems to random inputs using both classical transform and modern state space techniques.
Prerequisite(s): STAT 4714 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ECE 5605 
BMES 5534 - Advanced Computational Methods and Modeling for Biomedical Applications (3 credits) 
Methods of biomedical computational model development, solutions of ordinary and partial differential equations in mathematical models for biomedical applications, and current topics in biomedical modeling. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5554 - Imaging and Computing in Medicine (3 credits) 
Introduction to computing, processing, programming, and simulation fundamentals applications within medicine. Mathematical theory underlying signal processing, including Fourier transforms, sampling, quantization, correlation, and filtering. Segmentation techniques for imaging processing. Computational modeling including finite element modeling, computational physiology, and complexity and systems medicine. Data science , artificial intelligence, and deep learning applications in medicine. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5574 - Advanced Biomaterials (3 credits) 
Materials for medical applications. Basic material types and properties, functional uses of materials in medical applications, and tissue response mechanisms. Integrated design issues of multicomponent material design in prosthetic devices for hard and soft tissues, orthopedics, cardiovascular, and drug delivery applications. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: MSE 5574G 
BMES 5604 - Cancer Detection and Therapeutics (3 credits) 
Complexities and characteristics of cancer. Cancer progression and metastasis. Methods of tumor modeling. Cancer diagnosis methods including biopsy, pathology, and medical imaging. Cancer therapy methods including surgery, transplantation, energy-based therapies, and chemotherapeutic and immunotherapy agents. Decision-making strategies for tumor therapy. Case studies of cancer patients. Pre: Graduate Standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5614 - Multiscale Cancer Engineering (3 credits) 
A multidisciplinary, multiscale approach to analyzing cancer etiology, progression, detection, and therapy. Traditional and emerging methods of analyzing biomolecular aspects of cancer. Tumor microenvironment modeling and analysis. Physical oncology-inspired cancer therapy.
Prerequisite(s): BMES 5044 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5644 - Basic Concepts in Cancer Biology (2 credits) 
This course introduces fundamental concepts in cancer biology including etiology, genetic abnormalities, gene expression reprogramming, signal transduction aberration, and cancer stem cells that contribute to cancer development, progression, heterogeneity, and treatment response. Each lecture will focus upon a specific type of cancer (breast, bladder, ovarian, brain, prostate, and hematologic cancer) and highlight foundational knowledge in cancer biology. These include oncogenesis, genetic drivers and functional genomics in cancer, cancer stem cells and metastases, immunotherapy, and signaling in the tumor microenvironment. Pre: Graduate Standing.
Instructional Contact Hours: (2 Lec, 2 Crd) 
BMES 5714 - Biomedical Microdevices (3 credits) 
The goal of this course is to build the foundation necessary for engineering research in micro- and nano- biotechnology. The course will be broken down into four major area: micro- and nano- fabrication techniques, the fundamentals of microfluidics, micro- and nano- particle manipulation, and engineering aspects of cells and their membranes. The culmination of the course will provide students the knowledge required to create biomedical micro- and nano- devices with a focus on the unique physics, biology and design aspects at these scales. Students will be expected to know undergraduate engineering, physics, and calculus. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5724 - Biomedical Nanoengineering (3 credits) 
Major concepts in the design, production, and utility of micro- and nanotechnologies in biomedicine. Critical instrumentation, strategies for fabrication at the micro- and nanoscale, relevant nanoscale materials, engineering principles, and practical applications to biomedicine. Designed primarily for graduates who have a long-term academic and professional goals in the fields of biomedical engineering and biotechnology. Pre: Graduate Standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 5764 - Modeling MEMS and NEMS (3 credits) 
Modeling MEMS and NEMS is about the construction, analysis, and interpretation of mathematical and computational models microelectromechanical and nanoelectromechanical systems (MEMS and NEMS). A goal throughout the course will be to develop a physical intuition for the fundamental phenomena at these small scales. The material covered will be broad and multidisciplinary including: dimensional analysis and scaling; a review of continuum mechanics; fluid dynamics, elasticity, thermal transport and electromagnetism at the micro and nanoscales; the modeling of a variety of new MEMS/NEMS devices; and approaches beyond the continuum theory including stochastic and deterministic methods. Graduate standing required.
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ME 5764 
BMES 5904 - Project and Report (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 5944 - Seminar (1 credit) 
Instructional Contact Hours: (1 Lec, 1 Crd) 
BMES 5974 - Independent Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 5984 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 5994 - Research and Thesis (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 6064 - Clinical Rotation (2 credits) 
The course gives the student both a broad view of the use of engineering principles in medicine and general clinical care, together with an in-depth study of a particular aspect of medicine under the direct supervision of a physician. The student is allowed to observe the operation and maintenance of various clinical modalities, systems, and devices under the guidance of a working engineer or technician. The student participates in clinical rounds and image reading sessions to gain insight into the actual operation and needs of departments using medical imaging modalities. Pre: BME Ph.D. graduate students who have finished first year of study.
Instructional Contact Hours: (2 Lab, 2 Crd) 
BMES 6125 - Biodynamics & Control (3 credits) 
Study of human movement dynamics and neuromuscular control of multi-degree-of-freedom systems. 6225: Computational simulation of forward-dynamics and state-space linear control of human movement to investigate functional performance and neuromuscular pathology. 6226: Applied laboratory-based investigation and research design of human movement-control through state-of-the art measurement techniques.
Prerequisite(s): ESM 5224 or BMES 5124 or (ESM 4204 and ESM 5314) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 6225 
BMES 6126 - Biodynamics & Control (3 credits) 
Study of human movement dynamics and neuromuscular control of multi-degree-of-freedom systems. 6225: Computational simulation of forward-dynamics and state-space linear control of human movement to investigate functional performance and neuromuscular pathology. 6226: Applied laboratory-based investigation and research design of human movement-control through state-of-the art measurement techniques.
Prerequisite(s): ESM 5224 or BMES 5124 or (ESM 4204 and ESM 5314) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 6226 
BMES 6164 - Computational Modeling in Impact Biomechanics (3 credits) 
Dynamic modeling of the human body subjected to transient impact loading. A combination of finite element analysis and multi-body simulated techniques. Utilized software packages with dynamic solvers. Applications include computer-aided design for automobile safety, sports biomechanics, and military restraint systems.
Prerequisite(s): (BMES 5164 or ME 5754) or (ESM 5014 and ESM 5314) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
Course Crosslist: ESM 6164 
BMES 6174 - Advanced Human Modeling: Injury and Tissue Biomechanics (3 credits) 
Serves as a continuation of Impact biomechanics (BMES 5164) and computational biomechanics (BMES 6164), which uses Madymo. Basics of the finite element method as it applies to high-rate phenomena. Focus will be on practical problems and the use of commercial codes for solving vehicle crashworthiness and biomechanics problems. Theory will be presented when it is useful for application to the problem. Real world examples from biomedical engineering, automobile safety, military applications, and sport biomechanics are used.
Prerequisite(s): (BMES 5164 or ME 5754) and (BMES 6164 or ME 6754) 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 6194 - Advanced Movement Assessment (3 credits) 
This course will expand on previous course work and provide a detailed understanding of the methods used to collect human movement data, how to process data and interpretation of data output for the assessment of human movement. This course will also evaluate current literature in the area of human biomechanics and the application of these techniques in research and clinical settings.
Prerequisite(s): BMES 5124 or ESM 5224 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 6534 - Medical Health Physics (3 credits) 
Physical and biological aspects for the assessment of and protection from ionizing radiation in medical environments. Biological consequences of human radiation exposure. Principles of ionizing radiation protection. Radiation exposure recommendations and regulations. Radiation shielding, design, personnel monitoring, and medical health physics instrumentation.
Prerequisite(s): BMES 6544 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 6544 - Radiological Physics (3 credits) 
Nature and fundamental concepts of ionizing radiation. Radiological principles, radiation interactions, production of radiation and radiation dosimetry. Radiation quantities, attenuation and stopping power, charged particle and radiation equilibria and radioactive decay. Photon interactions, charged and uncharged particle interactions, x-ray production and quality and dosimetry concepts. Pre: Graduate standing.
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 6554 - Radiation Therapy Physics (3 credits) 
The physics of radiation therapy through the use of radiation producing equipment, character of photon and electron radiation beams, radiation dose functions, computerized radiation treatment planning, brachytherapy, special radiation treatment procedures, quality assurance, and radiation shielding for high energy facilities.
Prerequisite(s): BMES 6544 
Instructional Contact Hours: (3 Lec, 3 Crd) 
BMES 6984 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 7994 - Research and Dissertation (1-19 credits) 
Instructional Contact Hours: Variable credit course 
BMES 29844 - Special Study (1-19 credits) 
Instructional Contact Hours: Variable credit course